In China，the research on environmental protection of drinking water source is still in its beginning and exploring stage. We need to design and research on information system frame of drinking water source. The paper introduced the background, the system design goals and the main functions of drinking water source integrated management information system of Hainan province. The system has many characteristics, such as practicability, interactivity, developable, and intelligent, etc. The system can enhance environmental monitoring and management ability of drinking water source. Drinking water monitoring early warning and dynamic management will be achieved by the system. The overall level of environmental protection on drinking water source will be promoted.