Moistube-irrigation is a new water-saving irrigation technology with low energy consumption and broad application prospects. To reveal the effects of tube depth (D5, D15, D20) and pressure head (H100, H150, H200) on wetted zone under moistube-irrigation, an indoor experiment was conducted. Results showed that the diffusion rate of wetted zone in any directions under different pressure heads was: H200＞H150＞H100; The diffusion rate of wetted zone in the vertical upward and the horizontal direction under different tube depths were: D5＞D20＞D15, whereas that in the downward direction was: D20＞D15＞D5. The radius of wetted zone under different tube depth and pressure head was: H200＞H150＞H100 and D5＞D15＞D20. The effects of individual factors and their interaction on the values of Rmax followed the descending order of H＞D＞H*D, whereas that on the change rate of wetted-zone radius followed the descending order of H＞H*D＞D.