In order to determine the suitable maize planting density and irrigation mode in the north region of Shanxi Province, the experiment of mulched drip irrigation is carried out in the maize field in Yanggao County, Shanxi Province in 2015. The effects of various combinations of planting density and irrigation times on water content, water consumption, the growth and development of plant, and water use efficiency in maize fields are studied. The results show that the planting density and irrigation times have a significant effect on maize growth, which affects maize yield. Under the combination of the planting density of 82 500 plants/hm2 and the irrigation times of 3 during the growing period, the growth, water use efficiency and yield of maize are the best. It is the optimum combination with a yield of 8 418 kg/hm2, a water consumption of 4 057.03 m3/hm2, and a water use efficiency of 2.08 kg/m3.