In order to analyze the effect and uniformity of herbicide application during the integrated irrigation of micro-spray water and herbicide, the experiment of applying herbicide with water in the field micro-spray belt is carried out in Wuwei. The commonly used 32 oblique 5-hole micro-spraying belt is used as irrigation equipment, with a length of 40 m. Under the normal working pressure of 55 kPa and the total dose of 1.522 5 kg/hm2, the concentration of the liquid in the applicator is adjusted (test area A: 1.5 g/ L, area B: 2.0 g / L, area C: 3.0 g / L) The herbicidal effect and uniformity of application of the micro-spray zone with herbicide application with water are analyzed. The results show that the test A, B and C areas are in the direction of vertical micro-spraying zone, and the control effect of weed plants increases first and then decreases, which is consistent with the water distribution of micro-spray zone. In the case of the same total herbicide volume, at the 3 m position of the micro-spray zone, A1 and B1 and C1 are significantly different (P<0.05), and the difference between the two concentrations at 20 m is not significant. There is a significant difference between A1, B1 and C1 at 37 m (P<0.05). The uniformity of the weeds in the direction of the micro-spray belt gradually decreases, and the uniformity of the vertical micro-spray belt becomes larger and then smaller. The uniformity of weed control in test area C is significantly lower than that in areas A and B. The uniformity Cu of A and B areas was around 0.98, and the maximum value of Cu in area C was 0.98, and the minimum value is only 0.78. The difference is significant. Based on the improvement of the uniformity of the micro-spraying application and the weed control effect, the concentration of 2.0 g/L is better when the herbicide is applied by the micro-spraying water.