Abstract：High performance concrete design the mixture ratio mostly based on the strength, mix design with durability has not yet been in-depth studied. In order to effectively meet the durability requirements, this paper uses orthogonal experiment method to conclude the optimal mixture ratio, on the basis of workability, mechanical properties and durability properties of HF abrasion-resistant concrete. The results showed that: HF abrasion-resistant concrete optimal orthogonal combination is that the water cement ratio is 0.35, fly ash replacement rate is 25%, HF mixing amount is 2.5%, sand ratio is 35%. In a Qinghai hydropower station engineering application, the forming concrete has good durability, and meet the requirement of engineering design.