According to the Hotan River Basin data segment runoff data from1953 to 2014,and Wada weather precipitation (0.1mm),air
temperature,humidity (1%),the Mann-kendall mutation test,power spectrum analysis method and mold the coefficient differential quadrature method are used to analyze climate and runoff characteristics of the Hotan River Basin. The results show that Hotan River changes in rainfall are not significant,watershed temperature varies significantly. Precipitation changes every five years,the year 2001 mutated,the temperature change every 13 years,the year 1997 mutated. Hotan River runoff fluctuations represented an upward trend at the rate of 0.312 3,after standardization variation coefficient was 0.28,indicating that runoff inter-annual variability is relatively large and unstable. The Hotan River annual runoff is a little more than 3.2% or 0.8% less than the normal. The impact of climate change on runoff is mainly caused by temperature.