Ｒiver health assessment can judge and evaluate whether a river is in a healthy state，which not only helps river management department to determine management activities，but also provides a scientific basis for river protection and restoration． Based on the analysis of the connotation and index system of Liudong Ｒiver＇s health in Guizhou Province，this paper constructs a river health evaluation system consisting of 5 criteria layers and 15 index sets，including river physical characteristics，hydrological and water resources characteristics， water quality status，aquatic organisms，and social service functions． The health assessment score of Liudong Ｒiver was calculated by combining analytic hierarchy process and comprehensive assessment method． Our results show that the total health assessment score of Liudong Ｒiver is 82．32，and the river integrity scores of the eight divided sections are ranged from 82．91 to 89．34． The whole Liudong Ｒiver basin is generally in a healthy state，but some indexes of some river sections are still in an unhealthy state． Predictable measures should be taken to effectively control the occurrence or development of river ecosystem damage and significantly reduce the probability of ecosystem development towards an unrecoverable state and ecological restoration investment．