The water transfer projects of the new town in northwestern China usually have the characteristics of long distance, high lift, relatively small flow, many fluctuations along the line, high water supply guarantee rate, and outdoor water hammer prevention measures should consider the impact of cold weather on the Northwest China. The water transfer project of a new town in northern Shanxi is located in the southern edge of the Maowusu Desert. The water is pumped into the inlet pool of the pressurized pumping station through the pre-buried steel pipe in the dam, and then the water is taken from the inlet pool, pressurized by the water pumps, water is transported along the right bank bed to the downstream, and climbs along the vertical contour line at 1.26 km to the top of the slope, and then transports water along the road to the water plant. The pipeline is made of steel and ductile iron. The total length of the water pipeline is 10.5 km, with many fluctuations along the pipeline and the design water head is 157.7 m. Based on the project, the key technology of selection design for long-distance high-lift and multi-fluctuation water transfer projects in the northwest region are introduced, which can be used as reference for selection design of similar water transfer projects.